Elena Sokolinskaya

Research advisor: Professor Konstantin Lukyanov

Program entry year: 2019

Graduated from MSU, Faculty of Biology in 2019

Research project: Genetically encoded fluorescence probes for studying intracellular transport and activity of SARS-CoV-2 proteins

Research interests: Fluorescent protein-cell labeling and its application in live-cell imaging, 3D chromatin architecture, epigenetics, genetically encoded fluorescent sensors based on live-cell imaging, screening platforms for anti-SARS-CoV-2 drug discovery, SARS-CoV-2 fluorescent microscopy, developing of new chemogenetic tools for mammalian neurophysiology

Publications:

• Opbp is a new architectural/insulator protein required for ribosomal gene expression. Zolotarev N., Maksimenko O., Kyrchanova O., Sokolinskaya E., Osadchiy I., Girardot Ch., Bonchuk A., Ciglar L., Furlong E.E.M., Georgiev P.  Nucleic Acids Res. 2017 Dec 1; 45(21):12285-12300. doi: 10.1093/nar/gkx840.
• Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity. Kolesov D.V., Ivanova V.O., Sokolinskaya E.L., Kost L.A., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.M. Mol Biol Rep. 2021 May; 48(5):4549-4561.  doi: 10.1007/s11033-021-06480-0.

• Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLpro. Elena L. Sokolinskaya, Lidia V. Putlyaeva, Vasilisa S. Polinovskaya, Konstantin A. Lukyanov. International Journal of Molecular Sciences. 2022 Jul 15; 23(14):7826. doi: 10.3390/ijms23147826.

Conference presentations:

Tracking SARS-CoV-2 membrane proteins and measuring papain-like protease activity using live cell fluorescence microscopy. E.L. Sokolinskaya, L.V. Putlyaeva, A.A. Gorshkova, K.A. Lukyanov. Focus on Microscopy 2022 (FOM 2022), University of Utrecht, University of Amsterdam, The Netherlands, Online mode, 2022 April 10-13. Poster presentation

Grants:

2020-2022 – RFBR 20-04-60370 “Genetically encoded fluorescence probes for studying the dynamics of intracellular transport and interactions of SARS-CoV-2 proteins and development of safe cell screening platforms”