Konstantin Gilep

Research advisor: Svetlana Dubiley

Program entry year: 2022

Graduated from BSU, Faculty of Chemistry in 2019
Skoltech, Life Science in 2021

Research project: MurT-MurA type II toxin-antitoxin pair from Muribaculum sp. An289 comprises a Cas2-like ribonuclease toxin and an antitoxin from a new family.

Research interests: prokaryotic toxin-antitoxin systems

Publications:

1) Bikmetov,D., Hall,A.M.J., Livenskyi,A., Gollan,B., Ovchinnikov,S., Gilep,K., Kim,J.Y., Larrouy-Maumus,G., Zgoda,V., Borukhov,S., et al. (2022) GNAT toxins evolve toward narrow tRNA target specificities. Nucleic Acids Res., 50, 5807–5817. https://doi.org/10.1093/nar/gkac356

2) Yagmurov,E., Gilep,K., Serebryakova,M., Wolf,Y.I., Dubiley,S. and Severinov,K. (2022) S51 Family Peptidases Provide Resistance to Peptidyl-Nucleotide Antibiotic McC. MBio, 13. https://doi.org/10.1128/mbio.00805-22

3) Faletrov,Y. V., Gilep,K.A., Falchevskaya,A.S., Horetski,M.S., Panada,J. V., Andrievskaya,E. V., Rudaya,E. V., Frolova,N.S., Brzostek,A., Plocinska,R., et al. (2020) In silico modeling of izoniazidsteroid conjugates interactions with cytochromes P450 of mycobacteria and their bioconversion in vitro by the cells. Biomeditsinskaya Khimiya, 66, 378–385. https://doi.org/10.18097/PBMC20206605378