Gelfand Laboratory

AboutTeamPublicationsFundingThesis defencesCourses

Start date – June 2016

The main research areas of the lab are systems biology, functional and comparative genomics.

The lab combines data on three-dimensional structure of chromatin, epigenetic state, and gene expression to obtain an integrated view of genome functioning in diverse eukaryotes, from human to amoebae. One more research direction is evolution of transcript splicing and editing. Comparative analysis of bacterial genomes yields numerous functional annotations of novel enzymes, transporters, and transcription factors; understanding of general principles of evolution of bacterial genomes and regulatory networks. Metagenomic studies are mainly performed in the areas of general or practical interest (coral disease, aphids, oil wells).

  • Genome analysis of E. coli isolated from Crohn’s disease patients. Rakitina D, Manolov A, Kanygina A, Garushyants S, Baikova J, Alexeev D, Ladygina V, Kostryukova E, Larin A, Semashko T, Karpova I, Babenko VV, Ismagilova R, Malanin SGelfand M, Ilina EN, Gorodnichev R, Lisitsyna E, Aleshkin G, Scherbakov P, Khalif I, Shapina M, Maev I, Andreev D, Govorun V. BMC Genomics. 2017 Jul 19;18(1):544. doi: 10.1186/s12864-017-3917-x. PMID:28724357

Research grants/Industry funded research

Analytical review of publicly available information on the potential use of phosphorus-mobilizing microorganisms to increase the fertility of soils

Skoltech Biomedical Initiative

Machine learning and pattern recognition for the development of diagnostic and clinical prognostic prediction tools in psychiatry line mental disorders and neurology

Skoltech Translational and Research Innovation Program – STRIP

Metagenomic approach for oil and gas industry

Systems biology fellowship

Interpretable model for chromatin interaction probability prediction
MSc 2019
MSc 2018
MSc 2017
Bioinformatics Lab Course
Comparative Genomics