The Skoltech Center for Life Science was established in May 2018 by uniting Center for Translational Biomedicine and Center for Data-Intensive Biomedicine and Biotechnology. Our Center’s NEWS and EVENTS.
Over the coming five years, CLS mission will be:
Research in the Center develops in the following main directions:
Current and ongoing research projects include:
Completed research projects:
STRIP 1 (A Platform Approach to Develop New Antibiotic Leads Based on Microcins). As a result of the project implementation preclinical trials of three peptide antibiotics developed in the Severinov laboratory have been performed.
STRIP 2 (Development of Personal Genetic Screening System). A customized microarray-based platform for detection of cardiologic diseases has been developed.
Ongoing research projects
1. Regulation of Brain Aging: mapping and regulatory changes in human brain transcriptome and epigenome during aging. Project leader: Philipp Khaitovich.
2. Study of organisation of neuronal response mechanisms in primates, rodents and invertebrates brain. Project leader: Philipp Khaitovich.
3. Development of an oilseed expedited selection technology based on high-throughput methods for genotyping and molecular phenotyping to ensure food security of the Russian Federation. Project leader: Philipp Khaitovich.
4. Big Neuro Data processing infrastructure to support new NeuroNet markets development (CoBrain-Analitycs). Project leader: Philipp Khaitovich.
5. Agricultural Development Program. Project leaders: Philipp Khaitovich, Konstantin Severinov, Georgy Bazykin.
6. Search and Development of New Genome-Editing Tools for Biomedicine and Biotechnology. Project leader: Konstantin Severinov. In this joint project with Feng Zhang lab novel CRISPR-Cas systems are being uncovered by bioinformatics means, validated experimentally, and assessed for genome editing applications.
7. Targeted delivery of siRNA in vivo to the liver and prostate. Project leader: Timofei Zatsepin.
8. Epitranscriptomics. Project leader: Olga Dontsova.
9. The Role of Long Noncoding RNAs in Normal and in Cancerous liver: Olga Dontsova.
CLS faculty were responsible for establishment of Skoltech’s Master of Science program in Biotechnology and Ph.D. programs in Molecular Biology, Bioinformatics, and Biotechnology. Most of the current Skoltech Master and Ph.D. students in the general area of life sciences are affiliated with the center and work under the supervision of Center faculty. Our students publish numerous papers in top scientific journals and many perform individual applied R&D projects supported by UMNIK program grants.
The Center has established and operates a molecular biology teaching laboratory and bioinformatics laboratory where students receive training and perform individual projects.
Master and Ph.D. students from the Center participated in the STRIP grants awarded by the Skoltech Center for Innovation and Entrepreneurship.
The Center spearheaded the Skoltech-UMNIK program that combines admission to our Master program with the UMNIK contest, which enables students to engage in innovation/entrepreneurial activities from day one.
The Center places Master and Ph.D. students for individual summer industry immersion programs.
Our work on discovery of new genome-editing tools has resulted in a joint PTA application with MIT.
PCT application No. PCT/US2016/038258, filed June 17, 2016, title “NOVEL CRISPR ENZYMES AND SYSTEMS”
PCT Application No. PCT/US2016/038238, filed June 17, 2016, title “NOVEL CRISPR ENZYMES AND SYSTEMS”