Olga Dontsova co-authored one more paper in Biomedicines


Professor Olga Dontsova has co-authored a paper “Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA” that has been recently published in Biomedicines journal. Recently, the authors of the papers have demonstrated the existence of distinct TERC gene expression products possessing different functions. In order to identify the factors responsible for the appearance and localization of the exact isoform of human telomerase RNA (hTR), the scientists investigated the roles of the factors regulating transcription DSIF (Spt5) and NELF-E; exosome-attracting factors ZCCHC7, ZCCHC8, and ZFC3H1; ARS2, which attracts processing and transport factors; and transport factor PHAX during the biogenesis of hTR. The data obtained revealed that ZFC3H1 participates in hTR biogenesis via pathways related to the polyadenylated RNA degradation mechanism. Full text of the paper is available here.