Alina Galivondzhyan

Research advisor: Professor Konstantin Severinov

Program entry year: 2021

Graduated from MSU, Faculty of Bioengineering and Bioinformatics in 2021

Research project: Study of topoisomerase I and RNA polymerase interaction and formation of their complex in E. coli

Research interests: DNA topology, topoisomerases, transcription, topoisomerase:RNA-polymerase interactions

Publications:

Sutormin, D., Galivondzhyan, A., Musharova, O., Travin, D., Rusanova, A., Obraztsova, K., Borukhov, S., & Severinov, K. (2022). Interaction between transcribing RNA polymerase and topoisomerase I prevents R-loop formation in E. coli. Nature communications, 13(1), 4524. https://doi.org/10.1038/s41467-022-32106-5

Sutormin, D. A., Galivondzhyan, A. K., Polkhovskiy, A. V., Kamalyan, S. O., Severinov, K. V., & Dubiley, S. A. (2021). Diversity and Functions of Type II Topoisomerases. Acta naturae, 13(1), 59–75. https://doi.org/10.32607/actanaturae.11058

Zinovkina, L. A., Galivondzhyan, A. K., Prikhodko, A. S., Galkin, I. I., & Zinovkin, R. A. (2020). Mitochondria-targeted triphenylphosphonium-based compounds do not affect estrogen receptor α. PeerJ, 8, e8803. https://doi.org/10.7717/peerj.8803

Conference presentations:

Interaction between E. coli RNA polymerase and topoisomerase I is essential to prevent R-loop accumulation. Alina Galivondzhyan, Dmitry Sutormin, Sergey Borukhov, Konstantin Severinov. EMBO DNA Topology in genomic transactions. September 2021. Poster presentation

RNAP:EcTopoI interaction is essential to prevent R-loops formation in Escherichia coli. Alina Galivondzhyan, Dmitry Sutormin, Konstantin Severinov. XXVIII International conference for students, graduate students and young scientists “Lomonosov”, Moscow, Russia. April 2021. Oral presentation

Genome-wide search for E. coli topoisomerase I DNA binding and cleavage motifs using ChIP-Seq and Topo-Seq methods. Dmitry Sutormin, Alina Galivondzhyan, Konstantin Severinov. XXVIII International conference for students, graduate students and young scientists “Lomonosov”, Moscow, Russia. April 2021. Co-author.

Identification of topoisomerase I binding sites and study of it’s role in trascriptional regulation in Escherichia coli. Alina Galivondzhyan, Dmitry Sutormin, Konstantin Severinov. XXVII International conference for students, graduate students and young scientists “Lomonosov”, Moscow, Russia. November 2020. Oral presentation

Identification of topoisomerase I binding and activity sites in E. coli. Alina Galivondzhyan, Dmitry Sutormin. 2nd MSU and Tokyo Institute of Tecnology (TIT) conference, Moscow, Russia. September 2019. Poster presentation

Effect of tryphenilphosphonium derivatives on human breast adenocarcinoma cells proliferation activity. Alina Galivondzhyan, Ludmila Zinovkina. MSU 15th Student conference, Moscow, Russia. April 2018. Oral presentation

Mitochondria-targeted antioxidant SkQ1 increases expression of several estrogen-dependent genes. Alina Galivondzhyan, Ludmila Zinovkina. MSU 14th Student conference, Moscow, Russia. April 2017. Poster presentation