Alena Drobiazko

Research advisor: Professor Konstantin Severinov

Program entry year: 2020

Graduated from Skoltech in 2019

Research project: Functional study of BREX system proteins and their interactions with phage inhibitors

Research interests: Prokaryotic defense system mechanisms, phage-host interactions

Publications:

• Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence. Isaev A., Drobiazko, A., Sierro, N., Gordeeva, J., Yosef, I., Qimron, U., Ivanov N.V., Severinov, K.  Nucleic Acids Research, 48(10), 5397-5406, 2020
• Drobiazko, A.Y.; Kasimova, A.A.; Evseev, P.V.; Shneider, M.M.; Klimuk, E.I.; Shashkov, A.S.; Dmitrenok, A.S.; Chizhov, A.O.; Slukin, P.V.; Skryabin, Y.P.; Volozhantsev, N.V.; Miroshnikov, K.A.; Knirel, Y.A.; Popova, A.V. Capsule-Targeting Depolymerases Derived from Acinetobacter baumannii Prophage Regions. Int. J. Mol. Sci. 2022, 23, 4971. https://doi.org/10.3390/ijms23094971

Conferences:

Methyltransferase BrxX (PglX) defines the site-specificity of the Type I BREX defence system from Escherichia coli HS. Alena Drobiazko, Artem Isaev, Evgeniy Klimuk, Konstantin Severinov. 2022 Microbiology Society Annial Conference in Belfast, UK. Flash talk and poster presentation

Academic mobilities:

Department of Protein – DNA Interactions, Institute of Biotechnology, Vilnius University, Lithuania
Dates: 08.10.2018-30.04.2019

Tim Blower laboratory in Durham University, UK
Dates: 11.02.2022-10.04.2022

Dmitrii Ghylarov research group, John Innes Centre, Norwich, UK
Dates: 11.04.2022-10.06.2022

Industry Immersion:
Company: Sirius
Project: Searching for protection mechanisms against CRISPR-Cas bacterial systems