Anastasia Smirnova

Research advisor: Dmitry Chudakov, Ilgar Mamedov

Program entry year: 2020

Graduated from MIPT, Department of Biological and Medical Physics in 2020

Research project: Application of VDJ recombination events probability for BCR and TCR study

Research interests: bioinformatical analysis of T- and B-cell receptors, effect of active L1 retrotransposons on cancer development

Conference presentations:

• Anastasia O. Smirnova, Yuri B. Lebedev, Ilgar Z. Mamedov, Alexander Y. Komkov “iROAR: a computational algorithm for multiplex PCR bias detection and correction in TCR repertoires datasets”, ESHG 2021, 28.08–31.08.2021, virtual conference due to Covid-19 limitations. Poster presentation
• A. Smirnova, T. Grigoryeva, A. Komkov, Y. Lebedev, T. Mora, A. Walczak, D. Chudakov, I. Mamedov. Estimation of recombination events probabilities and construction of rearrangement model for TCRγ. The 19th Immunology Winter School on Basic Immunology Research in Allergy and Clinical, 27.01–30.01.2022
• Anastasia Smirnova, Ilgar Mamedov, Thierry Mora, Aleksandra Walczak, Tatyana Grigoryeva, Yuri Lebedev, Dmitriy Chudakov. Evaluation of TCRγ generation probability using Bayesian statistics. ESHG 2022, 11.07–14.07.2022
• Смирнова А.О, Комков А.Ю., Салютина М.В., Ткаченко В.К., Цуканов А.С., Снежкина А.В., Кудрявцева А.В., Шубин В.П., Лебедев Ю.Б., Мамедов И.З. Влияние активности LINE-1 в опухолях колоректального рака на инфильтрацию специфических Т-клеток. Вычислительная биология и искусственный интеллект для персонализированной медицины-2022. 02.08-04.08.2022

Publications:

• Komkov, A., Smirnova, A., Miroshnichenkova, A., Volchkov, E., Olshanskaya, Y., Maschan, M., … & Mamedov, I. (2021). The use of non-functional clonotypes as a natural spike-in for multiplex PCR bias correction in immune receptor repertoire profiling. BioRxiv.
• Urazbakhtin, S., Smirnova, A., Volakhava, A., Zerkalenkova, E., Salyutina, M., Doubek, M., … & Mamedov, I. (2022). The Absence of Retroelement Activity Is Characteristic for Childhood Acute Leukemias and Adult Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences, 23(3), 1756.