Natalia Nikitchina

Research advisor: Professor Konstantin Severinov

Program entry year: 2019

Graduated from IKBFU, Faculty of Bioengineering and Bioinformatics in 2019

Research project:  Use of CRISPR-Cas editors for human mitochondrial genomes editing

Research interests: Mitochondrial biology, technologies for targeted editing of nuclear and mitochondrial DNA

Academic mobility:
University: University of Strasbourg, Strasbourg, France

Laboratory: Génétique Moléculaire, Génomique, Microbiologie (GMGM), https://gmgm.unistra.fr/

Dates: 01.02.2020 – 17.08.2020; 01.02.2021 – 30.06.2021

Publications:

• Future of human mitochondrial DNA editing technologies. Verechshagina, N., Nikitchina, N., Yamada, Y., Harashima, Н., Tanaka, M., Orishchenko, K., & Mazunin, I. Mitochondrial DNA Part A. 2019 Mar;30(2). DOI: 10.1080/24701394.2018.1472773

Conference presentations:

• Modification of RGEN/AsCpf1 elements for import and function inside of the human mitochondrion. Nikitchina N, Verechshagina N, Shebanov N, Vyatkin Y, Orishchenko K, Mazunin I. CRISPR 2018, Vilnius, Lithuania, 2018 June 20-23. DOI: 10.13140/RG.2.2.35230.43844 . Poster presentation
• Use of the Type 2 CRISPR-Cas systems for human mitochondrial genomes editing. Nikitchina N, Mazunin I, Entelis N, Tarassov I. 11th World Congress on Targeting Mitochondria 2020, Berlin, Germany, 2020 October 28-30. Short oral presentation 

Grants:

•  2017-2019 – Grant from the Russian Science Foundation № 17-75-20015 “Molecular genetics technologies of targeted human mitochondrial genome editing”
• 2017-2020 – State Task Grant  “Functional assessment of the modified mitochondrial DNA which is not subject to the formation of deletions”
• 2019-2021 – RFBR mс 19-29-04101 “Studying the mechanism of control of mitochondrial replication/transcription by development and application of the mtDNA CSBII editing technology”