Vera Brezgina (Shashkovskaya)

Research advisor: Professor Juri Kotelevtsev

Program entry year: 2021

Graduated from MSU, Faculty of Chemistry in 2019

Research project: Investigation of the Role of Microglia Polarisation  in the Development of Amyotrophic Lateral Sclerosis (ALS)

Research interests: Characterisation of microglia  in neurodegenerative diseases, microglia transfection, molecular and cellular mechanism of action of siRNAs on microglial polarisation, transgenic mice (DKO 11β-HSD-2/ApoE, FUS(1-359)), atherosclerosis.  

Publications:

•  DNA Aptamers to Thrombin Exosite I. Structure-Function Relationships and Antithrombotic Effects. V A Spiridonova, T M Novikova, V A Sizov, V S Shashkovskaya, E V Titaeva, A B Dobrovolsky, E B Zharikova, A V Mazurov. Biochemistry (Mosc). 
  2019 Dec;84(12):1521-1528. doi: 10.1134/S0006297919120113.
• Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthase inhibitors. Alexandra A Tsitrina, Igor V Krasylov, Dmitry I Maltsev, Irina N Andreichenko, Viktoria S Moskvina, Dmitry N Ivankov, Elena V Bulgakova, Mikhail Nesterchuk, Vera Shashkovskaya, Nataliya O Dashenkova, Vladimir O Khilya, Arsen Mikaelyan, Yuri Kotelevtsev. Glycobiology. 2021 Sep 9;31(8):959-974. doi: 10.1093/glycob/cwab038. 

• Phenotypic alteration of BMDM in vitro using small interfering RNA. Noreen Halimani *, Alexandra A. Tsitrina, Andrey Elchaninov, Anastasia Lokhonina, Timur Kh. Fatkhudinov, Mikhail Nesterchuk, Irina N. Andreichenko, Nataliya O. Dashenkova, Vera Brezgina, Timofei S. Zatsepin, Arsen Mikaelyan, Yuri Kotelevtsev*. Cells. 2022 Aug 11;11(16):2498. doi: 10.3390/cells11162498.

Grants:

• 2022-2023 – William Harvey grant “Effect of AAV-driven liver over expression of Cyp7a1 on the development of atherosclerosis in ApoE/HSD2 double knockout mice