Noreen Halimani

Research advisor: Professor Yuri Kotelevtsev

Program entry year: 2020

Graduated from: University of Zimbabwe Faculty of Sciences in 2018

Research project: Validation of pharmaceutical targets for the treatment of liver fibrosis using siRNA and small molecule approach

Research interests: Human immunology and NTDs diseases epidemiology, siRNA therapeutics, and plant biotechnology techniques

Industry Immersion:

Company: Biruch Innovation Center for EFKO Group

Project: Construction of yeast strain based on P.pastoris, which hyper-expresses Phospholipase A2 and has no antibiotic resistance gene integrated into its genome.

Publications

Halimani N, Nesterchuk M, Andreichenko IN, Tsitrina AA, Elchaninov A, Lokhonina A, Fatkhudinov T, Dashenkova NO, Brezgina V, Zatsepin TS, Mikaelyan AS. Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA. Cells. 2022 Jan;11(16):2498.

Tsitrina, A.A.; Halimani, N.; Andreichenko, I.N.; Sabirov, M.; Nesterchuk, M.; Dashenkova, N.O.; Romanov, R.; Bulgakova, E.V.; Mikaelyan, A.; Kotelevtsev, Y. 4-Methylumbelliferone Targets Revealed by Public Data Analysis and Liver Transcriptome Sequencing. Int. J. Mol. Sci. 2023, 24, 2129. https://doi.org/10.3390/ijms24032129

Halimani, N., Nesterchuk, M., Tsitrina, A.A. et al. Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment. Sci Rep 14, 2797 (2024). https://doi.org/10.1038/s41598-024-53089-x

Conference Presentation

• RNA interference in vitro for the development of macrophage-based cell therapy. Emerging Cell Therapies: Realizing the Vision of NextGen Cell Therapeutics, Keystone eSymposia on Molecular and Cellular Biology, Silverthorne, Colorado, USA Jan 25-27 2021 Poster Presentation

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