Brendan Wilcox

Research advisor: Professor Konstantin Severinov

Program entry year: 2016

Graduated from: 

• The Pennsylvania State University (2014)

• Skolkovo Institute of Science and Technology (2016)

Research project: Bacterial Type-II Toxin-Antitoxin Systems

Research interests: Physiological roles of bacterial TA systems, bacterial transcription/translation regulation, mechanisms of translation inhibition, the evolutionary development of TA systems.

Academic mobility:

University: Imperial College London

Laboratory: Dr Sophie Helaine

Dates: 16/1/17 – 30/1/17

University: Rowan University

Laboratory: Professor Sergei Borukhov

Dates: 21/8/17 – 13/11/17

University: Peter the Great St. Petersburg Polytechnic University

Laboratory: Professor Konstantin Severinov

Dates: 15/1/18 – 25/1/18 ; 17/6/19 – 22/7/19

Publications:

• Wilcox B, Osterman I, Serebryakova M, Lukyanov D, Komarova E, Gollan B, Morozova N, Wolf YI, Makarova KS, Helaine S, Sergiev P, Dubiley S, Borukhov S, Severinov K. Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle. Nucleic Acids Res. 2018 Sep 6;46(15):7873-7885. doi: 10.1093/nar/gky560. PMID: 29931259; PMCID: PMC6125619.
• Stepan V Ovchinnikov, Dmitry Bikmetov, Alexei Livenskyi, Marina Serebryakova, Brendan Wilcox, Kyle Mangano, Dmitrii I Shiriaev, Ilya A Osterman, Petr V Sergiev, Sergei Borukhov, Nora Vazquez-Laslop, Alexander S Mankin, Konstantin Severinov, Svetlana Dubiley, Mechanism of translation inhibition by type II GNAT toxin AtaT2, Nucleic Acids Research, Volume 48, Issue 15, 04 September 2020, Pages 8617–8625, https://doi.org/10.1093/nar/gkaa551
• Sumida T, Dubiley S, Wilcox B, Severinov K, Tagami S. Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway. ACS Chem Biol. 2019 Jul 19;14(7):1619-1627. doi: 10.1021/acschembio.9b00348. Epub 2019 Jun 24. PMID: 31188556.

Conference presentations:

• Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle. Molecular Genetics of Bacteria and Phages. University of Wisconsin. Madison, Wisconsin USA. 7/8/17-11/8/17. Poster presentation.