Funding

Research grants/Industry funded researchNext Generation ProgramSkoltech Biomedical InitiativeSkoltech Translational and Research Innovation Program – STRIPUMNIKSystems biology fellowship

Study of adaptation and interference by natural Type III CRISPR-Cas systems of bacterium T. thermophilus

Novel long non-coding RNAs as potential biomarkers for diagnostics of liver cancer

Chromatin interactions in single cells – Development of computational tools and analysis of experimental data

Study of the mechanisms of foreign DNA recognition by bacterial defense system BREX from Escherichi coli HS

Mechanisms of bacterial defense agianst bacteriophage infection

Integrative omics approach for studying brain evolution: lipidome, proteome, transcriptome, connectome, and chromatin in brain regions of human, chimpanzee, bonobo, and macaque

Topoligically associating domains in chromatin: a functional study

Study of the regulation of expression of the genes of the restriction-modification Kpn2I system

Study of DNA-protein interactions in terminal complexes of bacteriophages infecting thermophilic bacteria

Development of fluorescent indicators for quantitative measurement of intracellular parameters

Study of DNA topology influence on CRISPR adaptation efficiency

Relationship between interference and adaptation during the action of Type I-E CRISPR-Cas system of Escherichia coli

Editing of antibiotic producers’ genomes for increasing of the antibiotic biosynthesis efficiency and overcoming of the resistance.

Evolution of mutually exclusive exons and regulation of alternative splicing by competing RNA structures

Identification and functional validation of cancer-specific splicing changes caused by somatic mutations in structural pre-mRNA elements

Search for the biological role of the TERP protein encoded in telomerase RNA

Study of CRISPR array structure and diversity by deep quantitative profiling of spacer composition

CRISPR/Cas9 based genome engineering in P. putida

Determination the role of RNA helicase DDX3 in the process of protein biosynthesis in vitro and in vivo

lncRNA LL35 as a regulator of Foxa 2 expression in vitro and in vivo - a probable target for diagnostics and therapeutics

Identification of Key genetic/epigenetic Marker(s) in cervical carcinogenesis and development of corresponding Molecular Therapeutics for precision medicine of cervical cancer

Obtaining and biochemical characterization of Cas9 protein with CJSC

Study of the mechanism of bacterial defense system BREX inhibition with DNA mimic protein Ocr from phage T7

The role of CRISPR-Cas immunity system in the human pathogen Clostridium difficile

Computational approach for discovery of new CRISPR-Cas associated proteins

Towards classification of immunogenic T-cell epitopes based on physicochemical characteristics, self homology and the structure of recognizing T-cell repertoire

Investigation of RNA polymerase encoded by AR9 phage, a phage with uracil-containing DNA genome

Cancer cell - specific RNA interference in vivo

Novel chemical modifications in guide RNAs for genome editing by CRISPR-Cas9

A novel strategy for pre-mRNA splicing correction by site-specific pre-miRNA recruitment

Next Generation Program (Skoltech — MIT Joint Projects) covers the whole range of academic and institution development activities. That includes research, education, innovation and academic services towards establishing and promoting a mutually beneficial longterm bilateral collaboration between Skoltech and MIT, as well as further development of Skoltech work streams.

Regulation of Antitumor Response via Modulation of Ubr‐Ubiquitin Ligases In Vivo

Search and Development of New Genome Editing Tools for Biomedicine and Biotechnology

The Skoltech Biomedical Initiative (SBI) is an interdisciplinary cross-CREI program designed to get ready for collaboration with the Moscow International Medical Cluster at Skolkovo. The SBI is intended to nucleate new projects and to integrate them into a focused cross-CREI program that will refine and solidify Skoltech’s mission in biomedical relevant areas of research, education and innovation.

Magnetic nanoparticles and carbon nanotubes as enhancers for targeted RNA delivery in vivo

Personalized bacteriophage therapy of clostridium Difficile Infections

Machine learning and pattern recognition for the development of diagnostic and clinical prognostic prediction tools in psychiatry line mental disorders and neurology

Deciphering the cause of human pregancy lose by exome analysis of abortuses

Skoltech Translational and Research Innovation Program awards one year of funding for translational research to bridge the gap between laboratory and marketplace and drives innovation and entrepreneurship in Russia. The Program provides critical support for participating teams to help establish proof of concept and provide assistance with advancing their technology towards commercialization, including pre-start up identification of high potential market opportunities, intellectual property management, and, if appropriate, team development. It helps to ensure that the invention meets the market technological requirements and finds its niche. It is developed in collaboration with the Deshpande Center for Technological Innovation at the Massachusetts Institute of Technology (MIT). Both The Deshpande Center and MIT have a proven track record of success in technology commercialisation.

Metagenomic approach for oil and gas industry

Targeted delivery of modified RNAs to the liver – an alternative Hepatitis C therapeutics

Development of Personal Genetic Screening System

A Platform Approach to Develop New Antibiotic Leads Based on Microcins

Foundation of Assistance to Small Innovative Enterprises (Bortnik’s foundation) is a non-profit organization set up by the Russian Government in 1994, formed in accordance with the Decree of the Government. The Foundation is classified as one of Russia’s most important scientific development institutions. UMNIK is the pre-seed funding program aimed to support young individual scientists by providing 500 000 rubles as nonrefundable nontaxable grant through multi-staged selection; selection of the winners is carried out in accredited institute by the expert panel (scientists and experts, business representatives, foundation representatives) prepared by Skoltech and approved by the Foundation.

Main objectives of the program:
– Provide state support for young scientists who want to fulfill their potential through innovation, and encouraging participation of young people in science, technology and innovation;
– Conduct research by young scientists in order to implement their results in the economy;
– Preparing young scientists for creation of small innovative enterprises, necessary for the application of research results.

UMNIK awards:

2017

2016

2015

Comprehensive characterization of CRISPR-linked genes

Interpretable model for chromatin interaction probability prediction