Aleksandra Galitsyna and Mikhail Gelfand have co-authored a paper “Perspectives for the reconstruction of 3D chromatin conformation using single cell Hi-C data” that has been recently published in PLoS Computational Biology. In the article, the scientists present a novel reconstruction approach, DPDchrom, that incorporates basic knowledge whether the reconstructed chromatin conformation should be coil-like or globular and spring relaxation at contact sites. DPDchrom has several outstanding features compared to other algorithms for chromatin 3D structure construction. For instance, DPDchrom can naturally form globular conformation due to the presence of explicit solvent. Moreover, the researchers found that the reconstruction accuracy exponentially depends on the number of contacts per genomic bin allowing to estimate the reconstruction accuracy in advance. The authors applied DPDchrom to model chromosome configurations based on single-cell Hi-C data of mouse oocytes and found that these configurations differ significantly from a random one, that is consistent with other studies. Full text of the paper is available here.