Olga Dontsova has co-authored a recent review “How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript” that has been published in Biomedicines journal. Telomerase RNA is considered to have major functions as a template for telomeric repeat synthesis and as a structural scaffold for telomerase. However, investigations of its biogenesis and turnover, as well as structural data, have provided evidence of functions of telomerase RNA that are not associated with telomerase activity. The paper is focused on the specific features relating to the biogenesis and structure of human telomerase RNA that support the existence of an isoform suitable for functioning as an mRNA. The authors of the review believe that further investigation into human telomerase RNA biogenesis mechanisms will provide more levels for manipulating cellular homeostasis, survival, and transformation mechanisms. Full text of the article is available here.