Skoltech scientists Iana Fedorova, Aleksandra Vasileva, Polina Selkova, Olga Musharova, Ignatiy Goryanin, Daria Artamonova, Tatyana Zyubko and Konstantin Severinov have co-authored a paper “PpCas9 from Pasteurella pneumotropica — a compact Type II-C Cas9 ortholog active in human cells” that has been published recently in Nucleic Acids Research. The researchers have characterized two Cas9 orthologs from CRISPR/Cas systems type II-C – DfCas9 from Defluviimonas sp. 20V17 and PpCas9 from Pasteurella pneumotropica. Unlike DfCas9, the PpCas9 nuclease is active in human cells and potentially can broaden the range of Cas9 applications in biomedicine and biotechnology. Congratulations! Full text of the paper is available here.