2014

Antibiotic streptolydigin requires non-catalytic Mg2+ for binding to RNA polymerase. Zorov S, Yuzenkova Y, Nikiforov V, Severinov K, Zenkin N. Antimicrob. Agents Chemother, 2014 58, 1420-1424.

CRISPR-Cas: Outstanding questions remain. Severinov K. Phys Life Rev. 2014, 11, 146-148,

The C-terminal unmodified part of microcin B is required for DNA gyrase inhibition and antibiotic entry into sensitive cells. Shkundina I, Serebryakova M, Severinov K Bacteriol. 2014, 196, 1759-1767..

Enzymatic synthesis of bioinformatically predicted microcin C-like compounds encoded by diverse bacteria. Bantysh O, Serebryakova M, Makarova K, Dubiley S, Datsenko K, and Severinov K. Mbio, 2014 5, е01059-14.. (2014)

Pervasive generation of oppositely-oriented spacers during CRISPR adaptation. Shmakov S, Savitskaya E, Semenova E, Datsenko K. A, and Severinov K. Nucleic Acids Res., 2014 42, 5907-5916.

Structural basis for RNA polymerase promoter specificity switching by a phage factor. Tagami S, Sekine S, Minakhin L, Esyunina D, Akasaka R, Shirouzu M, Kulbachinskiy A, Severinov K, Yokoyama S. 2014 28, 521-531

Development of giant bacteriophage фKZ is independent of host transcription apparatus Ceyssens, P.-J, Minakhin L, Van den Bossche A, Yakunina M, Klimuk E, Blasdel B, De Smet J, Noben J, Bläsi U, Severinov K. Lavigne R. J Virol , 2014 88, 10501-10510

Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Tagami S, Sekine S, Minakhin L, Esyunina D, Akasaka R, Shirouzu M, Kulbachinskiy A, Severinov K, Yokoyama S.Genes Dev. 2014 Mar 1;28(5):521-31. doi: 10.1101/gad.233916.113.

The RimL transacetylase provides resistance to translation inhibitors microcin C and albomycin. Kazakov T, Kuznedelov K, Semenova E, Mukhamedyarov D, Datsenko K, Vondenhoff H, Tikhonov A, Agarwal V, Nair S, Van Aerschot V, Severinov K. J. Bacteriol, 2014 196, 3377-3385

Molecular basis of RNA polymerase promoter specificity switch revealed through studies of Thermus bacteriophage transcription regulator. Severinov K, Minakhin L, Sekine S-I, Lopatina A, Yokoyama S. Bacteriophage, 2014 4, е29399

Ribosome-controlled transcription termination is essential for production of antibiotic microcin C Zukher I, Novikova M, Tikhonov A, Nesterchuk M, Osterman I, Djordjevic M, Sergiev P, Sharma C, Severinov K. 2014 Nucleic Acids Res 2014., 42, 11891-11902

Remote control of induced dopaminergic neurons in parkinsonian rats. Dell’Anno M, Caiazzo M, Leo D, Dvoretskova E, Medrihan L, Colasante G, Giannelli S, Theka I, Russo G, Mus L, Pezzoli G, Gainetdinov R, Benfenati F, Taverna S, Dityatev A, Broccoli V. J Clin Invest. 2014 Jul 1; 124 (7):3215-29. PMID: 24937431

TAAR1-dependent effects of apomorphine in mice. Sukhanov I, Espinoza S, Yakovlev D, Hoener M, Sotnikova T, Gainetdinov R. Int J Neuropsychopharmacol. 2014 Oct; 17(10):1683-93. PMID: 24925023

In Vivo Amphetamine Action is Contingent on αCaMKII. Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova E, Kong E, Willeit M, Sotnikova T, Kudlacek O, Gether U, Freissmuth M, Pollak D, Gainetdinov R, Sitte H. Neuropsychopharmacology. 2014 May 29. doi: 10.1038/npp.2014.124. PMID: 24871545

Selective Deletion of GRK2 Alters Psychostimulant-Induced Behaviors and Dopamine Neurotransmission. Daigle T Ferris M, Gainetdinov R, Sotnikova T, Urs N, Jones S, Caron M. Neuropsychopharmacology. 2014 Sep;39 (10):2450-62. PMID: 24776686

Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Ferris M, Milenkovic M, Liu S, Mielnik C, Beerepoot P, John C, España R, Sotnikova T, Gainetdinov R, Borgland S, Jones S, Ramsey A. Eur J Neurosci. 2014, 40: 2255-63. PMID: 24754704

Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Pei Y, Lee J, Leo D, Gainetdinov R, Hoener M, Canales J. Neuropsychopharmacology. 2014 Sep;39 (10):2299-308. PMID: 24722355

Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors. Leo D, Mus L, Espinoza S, Hoener M, Sotnikova T, Gainetdinov R. Neuropharmacology. 2014 Jun; 81:283-91. PMID: 24565640

Handbook of Behavioral Genetics of the Mouse (Eds. Pietropaolo S., Crusio W.E. and Sluyter F.) Sotnikova T, Gainetdinov R. Chapter 15: ADHD. Cambridge University Press, UK, 2014

Neuronal Functions and Emerging Pharmacology of TAAR1. Espinoza S, Gainetdinov R, In book: Top Med Chem., 2014 DOI: 10.1007/7355_2014_78 2 Springer International Publishing, Switzerland 2014

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration. Herr K, Tsang Y, Ong J, Li Q, Yap L, Yu W, Yin H, Bogorad R, Dahlman J, Chan Y, Bay B, Singaraja R, Anderson D, Koteliansky V, Viasnoff V, Thiery J. Sci Rep. 2014 Oct 30;4:6835. doi: 10.1038/srep06835.

What do we know about ribosomal RNA methylation in Escherichia coli? Sergeeva O, Bogdanov A, Sergiev P. Biochimie. 2014 Dec 13. pii: S0300-9084(14)00375-7. doi: 10.1016/j.biochi.2014.11.019.

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice. Padrissa-Altés S, Bachofner M, Bogorad RL, Pohlmeier L, Rossolini T, Böhm F, Liebisch G, Hellerbrand C, Koteliansky V, Speicher T, Werner S. Gut. 2014 Nov 21. pii: gutjnl-2014-307874. doi: 10.1136/gutjnl-2014-307874.

Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: Interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties. Ilyinsky N, Shchyolkina A, Borisova O, Mamaeva O, Zvereva M, Azhibek D, Livshits M, Mitkevich V, Balzarini J, Sinkevich Y, Luzikov Y, Dezhenkova L, Kolotova E, Shtil A, Shchekotikhin A, Kaluzhny D. Eur J Med Chem. 2014 Aug 8;85C:605-614. doi: 10.1016/j.ejmech.2014.08.030.

Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly Azhibek D, Zvereva M, Zatsepin T, Rubtsova M, Dontsova O. Nucleic Acids Res. 2014 Nov 1;42(15):9531-42. doi: 10.1093/nar/gku688. Epub 2014 Jul 31.

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype . Yin H, Xue W, Chen S, Bogorad R, Benedetti E, Grompe M, Koteliansky V, Sharp P, Jacks T, Anderson D. Nat Biotechnol. 2014 Jun;32(6):551-3. doi: 10.1038/nbt.2884. Epub 2014 Mar 30.

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice. Bogorad R, Yin H, Zeigerer A, Nonaka H, Ruda V, Zerial M, Anderson D, Koteliansky V. Nat Commun. 2014 May 21;5:3869. doi: 10.1038/ncomms4869.

Knockdown and knockout of β 1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling . Speicher T, Siegenthaler B, Bogorad RL, Ruppert R, Petzold T, Padrissa-Altes S, Bachofner M, Anderson DG, Koteliansky V, Fässler R, Werner S. Nat Commun. 2014 May 21;5:3862. doi: 10.1038/ncomms4862.

The molecular mechanism of aminopropylation of peptide-nucleotide antibiotic microcin C. Kulikovsky A, Serebryakova M, Bantysh O, Metlitskaya A, Borukhov S, Severinov K, Dubiley S. J Am Chem Soc. 2014 Aug 6;136(31):11168-75. doi: 10.1021/ja505982c. Epub 2014 Jul 23.

Steroid signaling: ligand-binding promiscuity, molecular symmetry, and the need for gating. Lathe R, Kotelevtsev Y. Steroids. 2014 Apr;82:14-22. doi: 10.1016/j.steroids.2014.01.002. Epub 2014 Jan 21

Atherosclerosis and Alzheimer – diseases with a common cause? Inflammation, oxysterols , vasculature. Lathe R, Sapronova A, Kotelevtsev Y. BMC Geriatr. 2014 Mar 21;14:36. doi: 10.1186/1471-2318-14-36.

Ribosome: lessons of a molecular factory construction. Sergeeva O, Sergiev P, Bogdanov A, Dontsova O.

Exogenous α-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release. Ronzitti G, Bucci G, Emanuele M, Leo D, Sotnikova TD, Mus LV, Soubrane CH, Dallas ML, Thalhammer A, Cingolani LA, Mochida S, Gainetdinov RR, Stephens GJ, Chieregatti E. J Neurosci. 2014 Aug 6

Further insights into the pharmacology of the human trace amine-associated receptors: discovery of novel ligands for TAAR1 by a virtual screening approach. Cichero E, Espinoza S, Franchini S, Guariento S, Brasili L, Gainetdinov R, Fossa P. Chem Biol Drug Des. 2014 Dec