On the 08th of February 2023, as part of the Photonics Seminar Series, we will have the pleasure to have two students from Skoltech Center for Photonic Science and Engineering present their research results: Igor Sergeev and Petr Skakunenko.
When: On the 08th of February 2023, Wednesday, at 17:00 MSK time
Where: New Campus room E-B2-3007 / BigBlueButton
Igor Sergeev will give a talk entitled “Light-induced toxicity caused by synergetic effect of gold nanozymes and photodynamic dye encapsulated into submicron polymer shell“.
Igor Sergeev is 2nd year PhD student at the Center of Photonic Science and Engineering, Biophotonics group (Advisor: Prof. Dmitry Gorin). In his work Igor combines photonic, chemical and synthetic methods for biological applications.
Photodynamic therapy (PDT) is one of the most promising cancer treatment methodologies due to overall lower toxicity and minimal invasiveness. However, the tumor microenvironment (TME) is known to feature unique characteristics, such as mild acidity, hypoxia, and overproduction of H2O2 and glutathione (GSH). H2O2 is a strong oxidant, but is not very reactive because of its slow reaction kinetics with the majority of biomolecules.
The design of artificial enzymes based on nanoparticles also known as nanozymes has received a significant amount of attention during the last decades. Since the first-time discovery of peroxidase-like activity of ferromagnetic nanoparticles in 2007, many other types of both organic and inorganic nanoparticles have been recognized as promising alternatives to biological enzymes due to their low cost, stability, and robustness. To date, nanozymes have been already developed for different demands including cancer therapy, antibacterial therapy, biosensing and even environment protection.
To overcome the limitations of hypoxia, PDT might be combined with H2O2-responsive nanozymes with catalase-like activity increasing the total efficacy of the treatment. Since activity of nanozymes is overall lower compared to natural catalase, it might compensate for the risk of oxygen toxicity in living cells.
Petr Skakunenko will present “Efficient ultracold atoms source for quantum sensing based on an atom chip“.
Petr Skakunenko is a 2nd year MSc student at Photonics and Quantum Materials program (under Prof. Arcady Shipulin’s supervision) and MIPT (under Anton Afanasiev’s supervision). Petr has received his BSc degree from MIPT. The presented work is done at the Institute of Spectroscopy of the Russian Academy of Sciences (ISAN), where Petr is working on his thesis research. Petr specializes in atomic and laser physics, especially in ultracold atoms physics. Atom chip, created in ISAN with Petr’s participation, is the first atom chip created in Russia.
Localized atoms are used in many precise atomic interferometry experiments. The development of this trend has already resulted in the creation of a new generation of quantum sensors based on the measurement of the effect of physical fields on quantum degrees of freedom of atoms. Quantum sensors provide an accuracy higher than that of existing classical sensors. Sensors based on atomic interferometry for measuring inertial forces, including gravimeters, gradiometers, and gyroscopes belong to the most developed quantum sensors. The accuracy of modern atom gravimeters and gradiometers already exceeds the accuracy of many classical analogs, and their application demonstrates a high reliability.
We propose a new efficient source of ultracold atoms for quantum sensing based on the atom chip technology. It consists of a single-layer atom chip loaded by low-velocity intense beam (LVIS). We consider focusing of a low-velocity atomic beam into the atom chip’s trapping region using 2D-MOT in overdamped regime. We also developed a new wide-wire intermediate MOT on a chip which would increase the number of trapped atoms by a factor of 2.5 compared to the traditional MOT on a chip.