Start date – April 2014
As humans, we are always interested to know how exactly our species came to exist. Human evolution has resulted in a species that possesses an apparently unique set of phenotypic capabilities. Furthermore, humans are capable of modifying their environment through process of animal and plant domestication and cultivation. These evolutionary events resulted in reciprocal adaptations of humans and domesticated species. Some of these recent human adaptations might represent vulnerable points within otherwise well buffered functional networks, resulting in uniquely human disease susceptibilities.
In our laboratory, we search for molecular events underlying evolutionary adaptations of humans and some of the key domesticated species through integrative analysis of genetic, transcriptomic, and metabolomic data measured in modern and archaic humans, humans affected by cognitive disorders, related non-human primates, mammalian models, and domesticated species. Following this approach, we have identified several molecular mechanisms that potentially underlie the evolution of the human phenotype and identified changes in brain organization accompanying cognitive development, as well as functional decline in ageing and common cognitive disorders.
The research conducted in our laboratory is built on a combination of the following resources and instruments:
We use various combinations of these resources and instruments to get insights into complex biological problems, with the main focus on:
Supervisor – Philipp Khaitovich
|Team:||Nikolay Anikanov||Anna Vanyushkina||Denis Goryunov|
|Pavel Mazin||Svetlana Goryunova||Anna Egorova|
|Olga Efimova||Dmitry Zubkov||Ekaterina Yushina|
|Alina Chernova||Song Guo|
Research grants/Industry funded research
Systems biology fellowship