Graduated from Lomonosov Moscow State University, Biological faculty, Immunology department in 2014. Qualification: specialist in biochemistry (immunology), equivalent to Ms degree.
1. Gamma/delta T cell receptor repertoires in late prenatal development;
2. TCR structure-driven selection in naive human thymic regulatory T cells;
3. TCR repertoires and selection in effector helper T cell subsets.
Research interests: resident T cells, T cell memory, public and private immune response; T-cell based cancer cell therapy, evolution of immunity, neuroimmune interactions.
Immune repertoire (RepSeq) data analysis. R (tidyverse), Python, biostatistics.
DNA library preparation for massive parallel sequencing.
Immunobiology/cancer immunology background. Qualified in cytometry/FACS cell sorting, primary human cell cultures, general molecular biology techniques.
Egorov ES, Kasatskaya SA (co-first authors), Zubov V.N., Izraelson M., Nakonechnaya T.O., Chudakov D.M., Britanova O.V.The changing landscape of naive T cell receptor repertoire with human aging. Frontiers in immunology. 2018 9: 1618.
Davey MS, Willcox CR, Hunter S, Kasatskaya SA,et al., The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets, Nature Communications. 2018 May; 9:1760, DOI: 10.1038/s41467-018-04076-0.
Hunter S, Willcox CR, Davey MS, Kasatskaya SA, et al., Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations Journal of Hepatology, 2018 May; DOI: 10.1016/j.jhep.2018.05.007.
Izraelson M, Nakonechnaya TO, Moltedo B, Egorov ES, Kasatskaya SA, Putintseva EV et al. Comparative analysis of murine T-cell receptor repertoires. Immunology. 2018 Feb;153(2):133-144. doi: 10.1111/imm.12857. Epub 2017 Nov 27. Review.
Davey MS, Willcox CR, Joyce SP, Ladell K, Kasatskaya SA, James E. et al. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nature Communications, 2017 Mar 1;8:14760. doi: 10.1038/ncomms14760
Kasatskaya SA, Egorov ES, Nakonechnaya TO, Britanova OV. T-cell receptor analysis of the naïve and memory gamma/delta T-cells reveals clonal selection among Vδ1 subset. Acta Naturae 2017. 85 (9).