Mariia Vlasenok

Research Advisor: Professor Dmitri Pervouchine

PhD Program entry year: 2019

Research project: Association between intronic polyadenylation and alternative splicing in cancer.

Finished Skoltech Life Sciences MSc program in 2019 with research project “Profiling responses of MCF-7 cells to heat shock based on Pol II activity at distinct steps of transcription cycle” under supervision of Professor Konstantin Severinov and Professor Sergei Nechaev (Associate Professor at University of North Dakota). MSc Program entry year: 2017. Academic mobility in UND, USA, Grand Forks. Laboratory: Nechaev’s Lab. Dates: 20.09.2018 – 20.03.2019.

Industry Immersion:
Company: Sirius. Project: Brain renewal

BSc degree from MIPT, Department of Biological and Medical Physics, in 2017.

Research interests: Regulation of transcription and post-transcriptional modifications; Pol II promoter-proximal pausing, non-canonical DNA structures and their role in expression regulation.

Publications:
1. Varizhuk, A., Ischenko, D., Tsvetkov, V., Novikov, R., Kulemin, N., Kaluzhny, D., Vlasenok, M, Naumov, V., Smirnov, I., Pozmogova, G. (2017). The expanding repertoire of G4 DNA structures. Biochimie, 135, 54–62. https://doi.org/10.1016/J.BIOCHI.2017.01.003
2. Vlasenok, M., Varizhuk, A., Kaluzhny, D., Smirnov, I., & Pozmogova, G. (2017). Data on secondary structures and ligand interactions of G-rich oligonucleotides that defy the classical formula for G4 motifs. Data in Brief, 11, 258–265. https://doi.org/10.1016/J.DIB.2017.02.023
3. Varizhuk, A. M., Protopopova, A. D., Tsvetkov, V. B., Barinov, N. A., Podgorsky, V. V., Tankevich, M. V., Vlasenok, M. A., Severov, V. V., Smirnov, I. P., Dubrovin, E. V., Klinov, D. V., Pozmogova, G. E. (2018). Polymorphism of G4 associates: from stacks to wires via interlocks. Nucleic Acids Research, 46(17), 8978–8992. https://doi.org/10.1093/nar/gky729
4. Vlasenok, M., Levchenko, O., Basmanov, D., Klinov, D., Varizhuk, A., & Pozmogova, G. (2018). Data set on G4 DNA interactions with human proteins. Data in Brief, 18, 348–359. https://doi.org/10.1016/J.DIB.2018.02.081
5. Parrello D., Vlasenok M., Kranz L. and Nechaev S. (2021) Targeting the Transcriptome Through Globally Acting Components. Front. Genet. 12:749850. doi: 10.3389/fgene.2021.749850

Conferences:
1. M.Vlasenok, V.Mikova, D.Pervouchine. De novo identification of polyadenylation sites from RNA-seq data. RECOMB, June 22-25, 2020. Poster
2. M.Vlasenok, D.Pervouchine. De novo identification of polyadenylation sites from RNA-seq data. Annual Meeting of the RNA Society, May 25-June 4, 2021. Poster
3. M.Vlasenok, D.Pervouchine. Transcriptome sequencing suggests lariat polyadenylation. Computational Approaches to RNA Structure and Function, August 7-21, 2022. Presentation