Julia Gordeeva

Research advisor: Professor Konstantin Severinov 

Program entry year:  2018

Graduated from MIPT, Department of Biological and Medical Physics in 2017; Skoltech, Biotechnology Program in 2018

Research project: The mechanism of BREX system defensive action

Research interests: Prokaryotic defense system mechanisms, bacteria and phage interactions

Academic mobility:

University: Texas A&M University

Laboratory: Zeng Research Laboratory https://zenglab4.tamu.edu/, Department of Biochemistry & Biophysics

Dates: 1.11.2017-21.12.2017

University: University Of Texas Medical Branch

Laboratory: Leiman Research Laboratory https://scsb.utmb.edu/labgroups/leiman/, Department of Biochemistry and Molecular Biology

Dates: 19.03.2018-31.05.2018

University: Institute of Microbiology, Chinese Academy of Sciences

Laboratory: Xiang Research Laboratory http://www.im.ac.cn/sklmr/EN%20version/XiangH.html, State Key Laboratory of Microbial Resources

Dates: 1.04.2019 – 14.05.2019

Publications:

• BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site. Gordeeva J., Morozova N., Sierro N., Isaev A., Sinkunas T., Tsvetkova K., Matlashov M., Truncaite L., Morgan R.D., Ivanov N.V., Siksnys V., Zeng L., Severinov K. Nucleic Acids Res. 2019 Nov 12; doi: 10.1093/nar/gky1125.
• Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence. Isaev, A., Drobiazko, A., Sierro, N., Gordeeva, J., Yosef, I., Qimron, U., Ivanov, N. V., & Severinov, K. (2020).  Nucleic acids research, 48(10), 5397–5406. https://doi.org/10.1093/nar/gkaa290

Conference presentations:

• BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site. Gordeeva J., Morozova N., Sierro N., Isaev A., Ivanov N.V., Zeng L., Severinov K.  CRISPR2018, Vilnius, Lithuania, 2018 June 20-23. Poster presentation
• BREX is a new prokaryotic defense system. J.Gordeeva, N.Morozova, N.Sierro, A.Isaev, N.Ivanov, L.Zeng, K. Severinov. Global Young Scientists Summit, Singapore, 2020 January 14-17.
  Poster presentation

 Grants:

• 2020 – 2022 – RFBR grant №20-34-90079 “Study of prokaryotic BREX defense mechanism of action and self versus non-self differentiation”