Evgeniia Alekseeva

evg.alekseeva93@gmail.com

Research advisor: Georgii Bazykin

Program graduate year: 2022

Graduated from:
MSU, Biological faculty, Department of Human and Animal Physiology, specialist, 2010-2015;
Skoltech, Center of Life Sciences, master, 2016-2018

Research projects:
T-cell escape of SARS-CoV2
Phylogenetic analyzis of human B cell lineages
Adaptive dynamics in changing environment (Master thesis)

Research interests:
adaptive immunity, population genetics, host-pathogen coevolution, evolutionary biology

Academic mobility:
University: University of Santiago, Chille
Laboratory: Department of Physics, group of Yaroslav Ispolatov
Dates: 02.09.2017 – 30.10.2017

Publications:
Stanevich, O.V., Alekseeva, E.I., Sergeeva, M. et al. SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19. Nat Commun 14, 149 (2023). https://doi.org/10.1038/s41467-022-34033-x

Mikelov AI, Alekseeva EI, Komech EA, Staroverov DB, Turchaninova MA, Shugay M, Chudakov DM, Bazykin GA, Zvyagin IV. Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires. Elife. 2022 Sep 15;11:e79254. doi: 10.7554/eLife.79254. Epub ahead of print. PMID: 36107479.

Mukhina OA, Fomina DS, Parshin VV, Gushchin VA, Dolzhikova IV, Shchetinin AM, Chudakov DM, Alekseeva EI, Korostin D, Bazykin GA, Klink G, Logunov DY, Lysenko MA. SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case. Human Vaccines & Immunotherapeutics. 2022 Aug 01; doi: 10.1080/21645515.2022.2101334. PMID: 35914217

Klink GV, Safina KR, Nabieva E, Shvyrev N, Garushyants S, Alekseeva EI, Komissarov AB, Danilenko DM, Pochtovyi AA, Divisenko EV, Vasilchenko LA, Shidlovskaya EV, Kuznetsova NA; Coronavirus Russian Genetics Initiative (CoRGI) Consortium, Speranskaya AS, Samoilov AE, Neverov AD, Popova AV, Fedonin GG; CRIE Consortium, Akimkin VG, Lioznov D, Gushchin VA, Shchur V, Bazykin GA. The rise and spread of the SARS-CoV-2 AY.122 lineage in Russia. Virus Evol. 2022 Mar 5;8(1):veac017. doi: 10.1093/ve/veac017. PMID: 35371558

Alekseeva E, Doebeli M, Ispolatov I. Evolutionary adaptation of high-diversity communities to changing environments. Ecol Evol. 2020;00:1–13. https://doi.org/10.1002/ece3.6695

Ispolatov I, Alekseeva E, Doebeli M (2019) Competition-driven evolution of organismal complexity. PLoS Comput Biol 15(10): e1007388. https://doi.org/10.1371/journal.pcbi.1007388

Conference presentations:
“SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19″, Alekseeva EI, Stanevich O, Sergeeva M, Fadeev A, Komissarova K, Ivanova A, Simakova T, Vasilyev K, Shurygina A-P, Stukova M, Safina K, Nabieva E, Garushyants S, Klink G, Bakin E, Jullia Zabutova J, Kholodnaia A, Lukina O, Skorokhod I, Ryabchikova V, Medvedeva N, Lioznov D, Danilenko D, Chudakov D, Komissarov A, Bazykin G.

“Signs of positive selection in new rounds of affinity maturation during B cell memory reactivation”, Alekseeva EI, Mikelov AI, Komech E, Turchaninova M, Shugay M, Zvyagin I, Bazykin G, European Academy of Allergy and Clinical Immunology Hybrid Congress 2021;

“A model of ecological and evolutionary effects of climate change”, Alekseeva EI, Ispolatov YO, BIFI International Conference of Computational  Biology 2018, Zaragoza, Spain;

Awards:
Grant RFBR, project number 19-31-27001 (Аспиранты 2020)