Dominique Leboeuf

Research advisor: Professor Timofei Zatsepin

Program entry year: 2017

Graduated from the University of Montreal in 2008

Research project: Ubr-Ubiquitin Ligases of the N-end rule: Role in the adult liver and new targets in liver cancer

Research interests: Cancer, apoptosis, drug development, immunology

Publications:

Thiant S, Moutuou MM, Laflamme P, Leboeuf D, Guimond M. Imatinib mesylate inhibits STAT5 phosphorylation in response to IL-7 and promotes T cell lymphopenia in chronic myelogenous leukemia patients. Blood Cancer J. 2017 Apr; 7(4): e551. doi:10.1038/bcj.2017.29

Smekalova EM, Kotelevtsev YV, Leboeuf D, Shcherbinina EY, Fefilova AS, Zatsepin TS, Koteliansky V. lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference. Biochimie. 2016 Dec;131:159-172

Thiant S, Moutuou MM, Leboeuf D, Guimond M. Homeostatic cytokines in immune reconstitution and graft-versus-host disease. Cytokine. 2016 Jun;82:24-32

Gauthier SD, Leboeuf D, Gaboury L, Guimond M. SDF-1a and IL-7 treatment improve homeostatic proliferation of naïve CD4+ T cells after allogeneic stem cell transplantation, Biol Blood Marrow Transplant. 2015 Oct;21(10):1721-31

Hennion-Tscheltzoff O*, Leboeuf D^*, Gauthier SD, Dupuis M, Assouline B, Grégoire A, Thiant S and Guimond M. TCR triggering modulates the responsiveness and homeostatic proliferation of CD4⁺ thymic emigrants to IL7 therapy. Blood.2013 Jun 6;121(23):4684-93* Co-First Author.

Leboeuf D, Letellier K, Alos N, Edery P, Moldovan F. Do estrogens impact adolescent idiopathic scoliosis ? Trends Endocrinol Metab.2009 May;20(4):147-52.

Cerani A, Tetreault N, Menard C, Lapalme E, Patel C, Sitaras N, Beaudoin F, Leboeuf D, DeGuire V, Binet F, Dejda A, Rezende FA, Miloudi K, Sapieha P.Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell Metab.2013 Oct 1;18(4):505-18.

Favret S, Binet F, Lapalme E, Leboeuf D, Carbadillo J, Rubic T, Picard E, Mawambo G, Tetreault N, Joval JS, Chemtob S, Sennlaub F, Sangiovanni JP, Guimond M, Sapieha P. Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions. Aging.2013 Jun;5(6):427-44.

Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennety TE, Sapieha P. Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Cell Metab. 2013 Mar 5;17(3):353-71.

Conference presentations:

Leboeuf D, Nesterchuk M, Smekalova E, Mikaelyan A, Zatsepin T, Anderson D, Piatkov K. Ubiquitin ligases (Ubr): a new target for RNAi therapy of hepatocellular carcinoma. N-term 2017, Proteostasis via the N-terminus. Halle, Germany *Oral presentation

Leboeuf D, Nesterchuk M, Smekalova E, Mikaelyan A, Zatsepin T, Anderson D, Piatkov K. Ubr Ubiquitin ligases as modulators of inflammation in hepatocellular carcinoma. International Liver Conference, Paris, France. 2018

Leboeuf D, Zatsepin T, Anderson D, Piatkov K. Regulation of antitumor response via modulation of Ubr-ubiquitin ligases in vivo. American Association of Cancer Research, Washington, USA. 2017

Leboeuf D, Zatsepin T, Nesterchuk M, Smekalova E, Mikaelyan A, Anderson D, Piatkov K. Ubr Ubiquitin Ligases: New Targets for the Treatment of Hepatocellular Carcinoma. Shaping the Future; a Skoltech-MIT conference. Moscow, Russia. 2017

Leboeuf D, Zatsepin T, Anderson D, Piatkov K. Ubr Ubiquitin Ligases: New Targets for the Treatment of Hepatocellular Carcinoma. Enzymes in Drug Discovery, San Diego, USA. 2017