Dmitry Sutormin

Research advisor: Professor Konstantin Severinov

Program entry year: 2018

Graduated from MSU, Faculty of Bioengineering and Bioinformatics in 2018

Research project: Regulation of bacterial genome topology by topoisomerases

Research interests: Genome organization and topology, topoisomerases, connection between genome organization and cell physiology

Publications:

• Single-nucleotide-resolution mapping of DNA gyrase cleavage sites across the Escherichia coli D. Sutormin, N. Rubanova, M. Logacheva, D. Ghilarov, K. Severinov, Nucleic Acids Research, gky1222, https://doi.org/10.1093/nar/gky1222
• Diversity and functions of type II topoisomerases. Sutormin, A. Galivondzhyan, A. Polkhovskiy, S. Kamalyan, K. Severinov, S. Dubiley, Acta Naturae, 2021, vol. 13, no. 1, DOI: 10.32607/actanaturae.11058

Conference presentations:

• Whole genome DNA gyrase cleavage sites identification with single-nucleotide resolution. Sutormin, D. Ghilarov, N. Rubanova, M. Guo, M. Laub, K. Severinov. Chromosome architecture and topological stress workshop, National University of Andalusia, Baeza, Spain, 2018 October 8-10. Poster presentation
• Role of DNA topoisomerases in bacterial genome maintenance. Sutormin, A. Galivondzhyan, K. Severinov. Global Young Scientists Summit (GYSS 2020), Singapore, 2020. Poster presentation

• Identification of topoisomerase I binding sites and study of it’s role in transcriptional regulation in Escherichia coli. A. Galivondzhyan, D. Sutormin, K. Severinov. International Conference “Lomonosov 2020”, Moscow, Russia. Poster presentation
• DNA-gyrase re-positions on E. coli genome sites in accordance with transcription profile in different growth phases. D. Sutormin, K. Severinov. International Conference “Lomonosov 2020”, Moscow, Russia. Oral presentation
• Metagenomic analysis of bacterial communities associated with sponges from the White Sea. A. Rusanova, D. Sutormin, V. Fedorchuk, M. Ezhova, K. Severinov. International Conference, “BIATA 2020”, 2020 July 27-28, virtual. Oral presentation
• Bacterial communities of White Sea marine sponges. A. Rusanova, D. Sutormin, D. Travin, V. Fedorchuk, M. Ezhova, S. Dubiley. International Conference “Lomonosov 2021”, Moscow, Russia. Oral presentation
• Identification of binding and cleavage sites of topoisomerase I in the E. coli genome with ChIP-Seq and Topo-Seq. D. Sutormin, A. Galivondzhyan, K. Severinov. International Conference “Lomonosov 2021”, Moscow, Russia. Oral presentation
• RNAP:EcTopoI interaction is essential to prevent R-loops formation in Escherichia coli. A. Galivondzhyan, D. Sutormin, K. Severinov. International Conference “Lomonosov 2021”, Moscow, Russia. Oral presentation
• Presumable bacterial symbionts of the White Sea marine sponges. A. Rusanova, D. Sutormin, V. Fedorchuk, M. Ezhova, S. Toshchakov, Svetlana Dubiley, Konstantin Severinov. International Conference, “BIATA 2021”, 2021 July 12-15, virtual. Oral presentation
• Interaction between E. coli RNA polymerase and topoisomerase I is essential to prevent R-loops accumulation. A. Galivondzhyan, D. Sutormin, S. Borukhov, K. Severinov. EMBO Workshop “DNA Topology in genomic transactions”, 2021 Sep 20-23, virtual. Poster presentation
• Identification of topoisomerase cleavage sites with a single-base precision using Topo-Seq. D. Sutormin, D. Ghilarov, M. Logacheva, K. Severinov. EMBO Workshop “DNA Topology in genomic transactions”, 2021 Sep 20-23, virtual. Poster presentation

Grants & stipends:

• 2020-2022 – RFBR grant “PhD-Student” (“Аспиранты”) 20-34-90069. “Role of topoisomerases and DNA supercoiling in structure-functional organization of bacterial genome”
• 2019-2022 – Russian Federation President Stipend for Young Scientists