Anna Maikova

Research advisor: Professor Konstantin Severinov

Program entry year: 2015

Graduated from: SPbU, Faculty of Biology in 2014

Research project: The CRISPR-Cas system of human pathogen Clostridium difficile: function and regulation

Research interests: molecular microbiology, biotechnology, CRISPR-Cas systems, biofilms

Academic mobility:
1) Pasteur Institute, Paris, France

Laboratory: Laboratory of Pathogenesis of Bacterial Anaerobes, https://research.pasteur.fr/en/team/pathogenesis-of-bacterial-anaerobes/

Dates: 11.01.2016 – 30.06.2016; 2.10.2016 – 8.04.2

2) The Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

Laboratory: The Group of  Regulatory RNAs in Clostridia, https://www.i2bc.paris-saclay.fr/spip.php?article1040

Dates: 3.10.2017 – 30.06.2018; 1.03.2019 – 4.10.2019

Publications:

• The HSP70 chaperone machines of Chlamydomonas are induced by cold stress. Maikova A., Zalutskaya Z., Lapina T., Ermilova E. J Plant Physiol. 2016;204. doi:10.1016/j.jplph.2016.07.012.
• Temporal dynamics of methyltransferase and restriction endonuclease accumulation in individual cells after introducing a restriction-modification system. Morozova N., Sabantsev A., Bogdanova E., Fedorova Y., Maikova A., Vedyaykin A., Rodic A., Djordjevic M., Khodorkovskii M., Severinov K. Nucleic Acids Res. 2016;44. doi:10.1093/nar/gkv1490.
• Discovery of new type I toxin–antitoxin systems adjacent to CRISPR arrays in Clostridium difficile. Maikova A., Peltier J., Boudry P., Hajnsdorf E., Kint N., Monot M., Poquet I., Martin-Verstraete I., Dupuy B., Soutourina O. Nucleic Acids Res. Oxford University Press; 2018;46: 4733–4751. doi:10.1093/nar/gky124.
• New insights into functions and possible applications of Clostridium difficile CRISPR-Cas system. Maikova A., Severinov K., Soutourina O. Front Microbiol. Frontiers; 2018;9: 1740. doi:10.3389/fmicb.2018.01740
• Using endogenous CRISPR-Cas system for genome editing in the human pathogen Clostridium difficile. Maikova A., Kreis, V., Boutserin, A., Severinov, K., Soutourina, O. Appl. Environ. Microbiol. 2019.; AEM.01416-19. doi:10.1128/AEM.01416-19

Conference presentations:

• The CRISPR-Cas system of Clostridium difficile: function and regulation. Maikova, Semenova E., Severinov K., Soutourina O. Institute Pasteur “Microbiology Department Days”, Paris, France, 4 – 6 April 2016, poster presentation.
• The CRISPR-Cas system of Clostridium difficile: function and regulation. Maikova, Semenova E., Severinov K., Soutourina O. Institute Pasteur “Microbiology Department Days”, Beauval, France, 21 – 23 March 2017, poster presentation.
• The CRISPR-Cas system of Clostridium difficile: function and regulation. Maikova, Semenova E., Severinov K., Soutourina O. National Congress of the French Society for Microbiology, Paris, France, 9 – 11 October 2017, oral presentation.
• The CRISPR-Cas system of Clostridium difficile: function and regulation. Maikova, Semenova E., Severinov K., Soutourina O. I2BC Microbiology Department Minisymposium, Gif-sur-Yvette, France, 1 June 2018, poster presentation.
• The CRISPR-Cas system of Clostridium difficile: function and regulation. Maikova, Semenova E., Severinov K., Soutourina O. 6th International C. difficile Symposium, Bled, Slovenia, 12 – 14 September 2018, oral presentation.

Grants:

2015 -2018 – Vernadsky scholarship for the joint Russian-French postgraduate study. Project: “The CRISPR-Cas system of human pathogen Clostridium difficile: function and regulation.”