Alexander Martynov

Supervisor: Konstantin Severinov

Entry year to Skoltech – 2014

Previous research:

Master (Specialist) degree from Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, 2013

Master’s thesis: Investigation of main digestive peptidases classes from two species of darkling beetles: Tenebrio molitor and Tribolium castaneum; Supervisor: Elpidina E.N.

Research interests:

Currently my main field of interest is mathematical modeling of biological processes and systems biology. My projects involve modeling of various processes that involve bacterial infection by phage and CRISPR-like bacterial defense systems.

Academic mobility:
University: Harvard Medical School, Laboratory of Dr. Michel Springer, July 2015 – July 2016

Publications:

1. David Armisen, Rajendhran Rajakumar; Markus Friedrich; Joshua B Benoit; Hugh M Robertson; Kristen A Panfilio; Seung-Joon Ahn; Monica F Poelchau; Hsu Chao; Huyen Dinh; HarshaVardhan Doddapaneni; Shannon Dugan-Perez; Richards A Gibbs; Daniel ST Hughes; Yi Han; Sandra L Lee; Shwetha C Murali; Donna M Muzny; Jiaxin Qu; Kim C Worley; Monica Munoz-Torres; Ehab Abouheif; François Bonneton; Travis Chen; Li-Mei Chiang; Christopher P Childers; Andrew G Cridge; Antonin JJ Crumiere; Amelie Decaras; Elise M Didion; Elizabeth Duncan; Elena N Elpidina; Marie-Julie Fave; Cedric Finet; Chris GC Jacobs; Alys Jarvela; Emily J Jennings; Jeffery W Jones; Maryna P Lesoway; Mackenzie Lovegrove; Alexander Martynov; Brenda Oppert; Angelica Lilico-Ouachour; Arjuna Rajakumar; Peter N Refki; Andrew J Rosendale; Maria Emilia Santos; William Toubiana; Maurijn van der Zee; Iris M Vargas Jentzsch; Aidamalia Vargas Lowman; Severine Viala; Stephen Richards; Abderrahman Khila. The genome of the water strider Gerris buenoi reveals expansions of gene repertoires associated with adaptations to life on the water, BMC Biology, In press
2. Schoville SD, Chen YH, Andersson MN, Benoit JB, Bhandari A, Bowsher JH, Brevik K, Cappelle K, Chen MM, Childers AK, Childers C, Christiaens O, Clements J, Didion EM, Elpidina EN, Engsontia P, Friedrich M, García-Robles I, Gibbs RA, Goswami C, Grapputo A, Gruden K, Grynberg M, Henrissat B, Jennings EC, Jones JW, Kalsi M, Khan SA, Kumar A, Li F, Lombard V, Ma X, Martynov A, Miller NJ, Mitchell RF, Munoz-Torres M, Muszewska A, Oppert B, Palli SR, Panfilio KA, Pauchet Y, Perkin LC, Petek M, Poelchau MF, Record É, Rinehart JP, Robertson HM, Rosendale AJ, Ruiz-Arroyo VM, Smagghe G, Szendrei Z, Thomas GWC, Torson AS, Vargas Jentzsch IM, Weirauch MT, Yates AD, Yocum GD, Yoon JS, Richards S. A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae). Sci Rep. 2018 Jan 31;8(1):1931. doi: 10.1038/s41598-018-20154-1. IF: 4.259
3. Martynov A, Severinov K, Ispolatov I. Optimal number of spacers in CRISPR arrays. PLoS Comput Biol. 2017 Dec 18;13(12):e1005891. doi: 10.1371/journal.pcbi.1005891. IF: 4.587
4. Oppert B., Perkin L., Martynov A.G., Elpidina E.N.. Cross-species comparison of the gut: Differential gene expression sheds light on biological differences in closely related tenebrionids. J Insect Physiol. 2017 Mar 28. doi: 10.1016/j.jinsphys.2017.03.010. IF: 2.227
5. Savir Y.^*, Martynov A.^*, Springer M. (2017) Achieving global perfect homeostasis through transporter regulation. PLoS Comput Biol 13(4): e1005458. doi: 10.1371/journal.pcbi.1005458 IF: 4.587
6. Martynov A.G., Elpidina E.N., Perkin L. and Oppert B., Functional analysis of C1 family cysteine peptidases in the larval gut of Tenebrio molitor and Tribolium castaneum. BMC Genomics. 2015 Feb 14;16:75 doi: 10.1186/s12864-015-1306-x IF: 3.729
7. Oppert B., Martynov A.G., Elpidina E.N. Bacillus thuringiensis Cry3Aa protoxin intoxication of Tenebrio molitor induces widespread changes in the expression of serine peptidase transcripts. Comp Biochem Physiol Part D Genomics Proteomics. 2012 Sep;7(3):233-42 doi: 10.1016/j.cbd.2012.03.005 IF: 2.857

^* Co-first authorship

Poster presentations:

1. Martynov A., Severinov K. Ispolatov J., Optimal length of CRISPR arrays, MCCMB, Moscow, 2017
2. Martynov A., Severinov K. Ispolatov J., Optimal length of CRISPR arrays, Skoltech-MIT Conference, 2017
3. Martynov A., Savir, Springer M., Activity-dependent membrane transporter downregulation can lead to homeostasis. Information Technology and Systems, 2016

Report presentations:

1. Martynov A., Ispolatov J., Mathematical model of optimal CRISPR-array, 1st Annual Workshop of Skoltech/MIT Next Generation Program, 2016