The rapid acceleration of genomic and proteomic technologies has provided new insight on the molecular basis of disease. However, validation of therapeutic targets from this enormous collection of information has been limited by the slow pace of existing in vivo biological tools.

The discovery of RNA interference has revolutionized molecular biology. It has also become clear that the combination of modern drug delivery systems and RNA interference will similarly revolutionize drug therapy and the study of biology.siRNA

The mission of the Skolkovo Center for Biomedical Research is to develop a robust collaborative effort focused on the development and application of RNA technology for medicine and biology, with specific emphasis towards medical conditions of importance to Russia.

Our CREI combines expertise in Drug Delivery, Chemistry, Biology and Medicine between experts at in the US and Russia.

This multidisciplinary effort seeks to advance of science, generate new therapeutics, strengthen Russian institutions, and educate the next generation of Russian scientists.

Visions and Goals
  • The rapid acceleration of genomic technologies has provided new insight in the molecular basis of disease. The discovery of RNA interference has revolutionized biomedical research by removing limitations of in vivo target validation.
  • The Center will develop a robust effort focused on the development and application of RNA technology for medicine and biology.
  • The Center will combine expertise in Drug Delivery, Chemistry, Biology and Medicine between leading experts in US (MIT, UT Southwestern) and Russia (Moscow State University).
  • This multi-disciplinary international effort seeks to advance science, to generate new therapeutics, to strengthen Russian institutions, and to educate a next generation of Russian scientists.

The impact of the center is multifold and takes advantage of synergistic expertise between the home institutions.

  1. The development of clinically suitable, safe and effective siRNA delivery vehicles to a range of cells.  We anticipate specific and early impact in the area of liver disease and cancer, of significant importance to both Russia and the US.
  2. The application of RNA delivery towards in vivo biology. This technology will be applied to understand the genetic determinants of key aspects of liver biology and disease, including metabolism, cellular growth, fibrosis, and cancer.
  3. The establishment of multi-disciplinary educational efforts in Nanomedicine, RNA therapeutics and its application to biology.  A key goal of these efforts will be the development of a collaborative, multi-disciplinary training program between Russian and US institutions.  Leading venture capital firms in the US and Russia have been engaged to assist in the educational program, towards the development of a culture of innovation and translation at the newly established Skoltech Institute. Efforts would be dedicated towards the continued connection between Russian and American scholars, as well as the transition of these trainees to leadership positions in Russia.