Graduated from the Moscow State University, Biology Department
Entry year to Skoltech – 2016
Supervisor: Georgii Bazykin
Research project: Methods for inference of positive selection
My current work is focused on studying selection processes in parallel evolution of species. Indeed, what’s the probability of similar trait appearence in two closely related species? What about highly diverged species? How many parallel evolution events we can found in two independent lineages, and how to distinguish neutral and selective substitutions?
We compared the rate of parallel synonymous and nonsynonymous molecular evolution in different systematic groups. Orthologous groups alignments of closely related gammaridae species were used for this issue, and vertebrates exon alignments were added as a reference dataset. Where the same nucleotide substitutions had occurred in more than one lineage, nonsynonymous substitutions were found to be more frequent than synonymous ones. The excess of nonsynonymous parallel substitutions indicates prevalent positive selection at sites of parallel evolution in closely related species, and underscores the high role of positive selection in early sympatric divergence.
Diploma work: conducted at Moscow State University, Biological Faculty, Department of Vertebrate Zoology (under the direction of B.I. Sheftel). Topic: “The role of spatial structured environment in small mammal’s population dynamics”.
Valentina Burskaya, Sergey Naumenko, Georgii Bazykin “Evidence of Positive Selection in Parallel Evolution of Closely Related Gammarus Species Genomes” – Information Technology and Systems 2016, September, 25-30, Repino, St. Petersburg, Russia.
Olga Sigalova, Andrey Chaplin, Olga Bochkaryova, Pavel Shelyakin, Vsevolod Filaretov, Evgeny Akkuratov, Valentina Burskaya, Mikhail S. Gelfand “Stability or Rapid Change? Genomic Analysis of Genus Chlamydia” – The Eighth Meeting of the European Society for Chlamydia Research, September 6-9, 2016, Oxford’s Town Hall, England.